Sympathomimetics may produce a wide range of adverse effects, most of which mimic the results of excessive stimulation of the sympathetic nervous system. These effects are mediated via the various types of adrenergic receptor, and the adverse effects of an individual drug depend to some extent upon its relative agonist activity on these different types of receptor at a given dose.

The acid of latanoprost has a plasma clearance of 0.40 l/h/kg and a small volume of distribution, 0.16 l/kg, resulting in a rapid half life in plasma, 17 minutes. After topical ocular administration the systemic bioavailability of the acid of latanoprost is 45%. The acid of latanoprost has a plasma protein binding of 87%. So, a milligram is a thousandth of a thousandth of a kilogram, and a milliliter is a thousandth of a liter. Notice there is an extra thousandth on the weight unit. Therefore, there must be 1,000 milligrams in a milliliter, making the formula for mg to ml conversion: Oral topical anaesthesia may interfere with swallowing, and numbness of the tongue or buccal mucosa may increase the danger of biting trauma. To convert milliliters to grams, multiply the volume (in ml) by the density of the ingredient (in g/ml). You need to factor in the ingredient density The systemic toxicity of local anaesthetics mainly involves the central nervous system and the cardiovascular system. Excitation of the CNS may be manifested by restlessness, excitement, nervousness, dizziness, tinnitus, blurred vision, nausea and vomiting, muscle twitching and tremors, and convulsions. Numbness of the tongue and perioral region may appear as an early sign of systemic toxicity. Excitation may be transient and followed by depression with drowsiness, respiratory failure and coma. There may be simultaneous effects on the cardiovascular system with myocardial depression and peripheral vasodilatation resulting in hypotension and bradycardia; arrhythmias and cardiac arrest may occur.inflammation, eyelid redness, swelling around the eye, eyelid itching, blurred vision, increased tear COVID-19 vaccines [footnote 1] used in the UK including information on dose, eligible ages, storage, stability and appearance. Comirnaty 3 Comirnaty 3 The manufacturer does not recommend the use of salbutamol during breastfeeding, unless the expected benefit is thought to outweigh any possible risk to the fetus. Inhaled salbutamol is likely to be present in human breast milk. Briggs and Schaefer state that inhaled salbutamol is generally considered compatible with breastfeeding, although very large maternal doses of inhaled beta 2 agonists may cause restlessness and tachycardia in the infant (Schaefer 2015). Side Effects

There are no adequate data from the use of latanoprost in pregnant women. Studies in animals have shown reproductive toxicity (see section 5.3). The potential risk for humans is unknown. General side effects: increased allergic symptoms, headache, irregular heart beat, cough, stuffy nose, It should be kept in mind that in case of insufficient efficacy of the fixed combination, results from studies indicate that the use of unfixed administration of Timolol bid and latanoprost once a day might be still efficient. Macular oedema, including cystoid macular oedema, has been reported during treatment with latanoprost. These reports have mainly occurred in aphakic patients, in pseudophakic patients with a torn posterior lens capsule, or in patients with known risk factors for macular oedema. Latanoprost / Timolol should be used with caution in these patients.

Children

We can also convert by utilizing the inverse value of the conversion factor. In this case 1 milliliter is equal to 0.0004 × 2.5 liters.